职称 副教授

学位 博士

电话 027-87282113

邮箱 wei-ji@mail.hzau.edu.cn

研究方向 水产动物疾病与免疫

 教育经历 

2000.8至2004.7  中国海洋大学，本科生/理学学士，生物技术

2004.8至2007.6  华中农业大学，研究生/农学硕士，水产养殖

2008.9至2011.6  中科院水生生物研究所，研究生/理学博士，遗传学

 主要职历 

2007.7至2008.8，中科院水生生物研究所，助理实验师；

2011.7至2012.6，中科院水生生物研究所，项目研究员；

2012.7至2016.12，jxf吉祥官网总站，讲师；

2017.1至今，jxf吉祥官网总站，副教授。

 科研成果 

主持课题：

1. 国家自然科学基金，pVHL对E2F1介导的生物学功能的影响极其分子机制（31301122），资助金额：20万，2014.01-2016.12。

2. 湖北省自然科学基金面上项目，TLR5M/TLR5S在黄颡鱼抗细菌感染中的作用及机制分析（2018CFB479），资助金额：5万，2018.01-2020.12。

3. 不同鲫鱼品系的低氧耐受力及其分子机制分析（水生所重点实验室开放课题）

4. 淡水生态与生物技术国家重点实验室开放课题，TLR4和TRIL基因在黄颡鱼抗鲇爱德华氏菌感染中的功能研究，资助金额：8万，2018.01-2018.12。

5. 农业部淡水养殖病害防治重点实验室开放课题，TLR5S/5M在黄颡鱼抗鲇爱德华氏菌感染中的作用及机制分析，资助金额：5万，2018.07-2020.07。

6. 横向课题，南美白对虾弧菌病防治产品研发，10万，2023

7. 横向课题，弧菌病防治产品噬菌体等微生态制剂的研发，10万，2024

8. 农业农村部淡水生物多样性保护重点实验室开放课题，黄颡鱼在鮰爱德华氏菌感染过程中血脑屏障通透性及脑免疫功能研究，5万，2023-2024

代表性学术论文：

1. Mengge Guo, Ruhan Sun, Zhengyan Wu, Anqi Li, Qin Wang, Zhangchun Zhao, Huimin Liu, Bingchao Wang, Ke Xiao, Zechao Shi, Wei Ji*. A comparative study on the immune response in the head and trunk kidney of yellow catfish infected with Edwardsiella ictaluri. Fish & Shellfish Immunology, 2024, 154: 109895.

2. Qin Wang, Zhangchun Zhao, Ruhan Sun, Zechao Shi, Yaqian Zhang, Bingchao Wang, Xuezhen Zhang, Wei Ji*. Bioinformatics characteristics and expression analysis of IL-8 and IL-10 in largemouth bass (Micropterus salmoides) upon Nocardia seriolae infection. Fish & Shellfish Immunology, 2024, 148: 109465.

3. Zhiwei Liao^#, Wei Ji^#, Chunrong Yang, Jianguo Su. TLR5M and TLR5S Synergistically Sense Flagellin in Early Endosome in Lamprey Petromyzon marinus, Switched by the N-Glycosylation Site N239. The Journal of Immunology, 2024, 212(5): 855-867. （共同第一作者）

4. Zhangchun Zhao, Sixue Liu, Chen Wu, Qin Wang, Yaqian Zhang, Bingchao Wang, Long Wang, Ruhan Sun, Mengge Guo, Wei Ji*. Bioinformatics characteristics and expression analysis of TLR3 and its adaptor protein TRIF in largemouth bass (Micropterus salmoides) upon Flavobacterium columnare infection. Gene, 2023, 872: 147450.

5. Yujie Yuan, Zechao Shi, Qin Wang, Mengge Guo, Le Yuan, Zhangchun Zhao, Sixue Liu, Chen Wu, Ruhan Sun, Bingchao Wang, Gang Ouyang, Wei Ji*. Molecular characterization and expression analyses of five genes involved in the MyD88-dependent pathway of yellow catfish (Pelteobagrus fulvidraco) responding to challenge of Aeromonas hydrophila. Fish & Shellfish Immunology, 2023, 137: 108712.

6. Ru-Han Sun, Kai-Wei Chen, Qin Wang, Zhen-Yu Huang, Bing-Chao Wang, Ze-Chao Shi, Wei Ji*. Blood brain barrier permeability and immune function of brain in rainbow trout responding to IHNV infection. Developmental and Comparative Immunology, 2022, 135: 104482.

7. Gang Ouyang, Ruhan Sun, Xinyu Wan, Le Yuan, Zechao Shi, Qin Wang, Bingchao Wang, Yanzhi Luo, Wei Ji*. Characterization, expression and function analysis of pfTLR5S and pfTLR5M in yellow catfish (Pelteobagrus fulvidraco) responding to bacterial challenge. International Journal of Biological Macromolecules, 2022,216 : 322–335.

8. Bingchao Wang, Fangzheng Zhu, Zechao Shi, Zhenyu Huang, Ruhan Sun,Qingchao Wang, Gang Ouyang*, Wei Ji*. Molecular characteristics, polymorphism and expression analysis of mhc II in yellow catfish (pelteobagrus fulvidraco) responding to Flavobacterium columnare infection. Fish & Shellfish Immunology, 2022, 125: 90-100.

9. Zheng-Ben Wu, Kai-Feng Meng, Li-Guo Ding, Sha Wu, Guang-Kun Han, Xue Zhai, Ru-Han Sun, Yong-yao Yu, Wei Ji * and Zhen Xu *. Dynamic interaction between mucosal immunity and microbiota drives nose and pharynx homeostasis of common carp (cyprinus carpio) after SVCV infection. Frontiers in Immunology, 2021, 12: 769775.

10. Chen Kaiwei, Zhao Feng, Ouyang Gang, Shi Zechao, Ma Lina, Wang Bingchao, Guo Ronghuan, Xiao Wuhan, Zhu Fangzheng, Wei Kaijian, Xu Zhen, Ji Wei*. Molecular characterization and expression analysis of Tf_TLR4 and Tf_TRIL in yellow catfish Tachysurus fulvidraco responding to Edwardsiella ictaluri challenge. International Journal of Biological Macromolecules, 2021, 167:746-755.

11. Wang Qingchao^#，Ji Wei^#， Xu Zhen. Current use and development of fish vaccines in China. Fish and Shellfish Immunology, 2020, 96: 223–234.（共同第一作者）

12. Jiang Rui, Zhang Guirong, Zhu Dongmei, Shi Zechao, Liao Chenlei, Fan Qixue, Wei Kaijian*, Ji Wei*. Molecular characterization and expression analysis of IL-22 and its two receptors genes in yellow catfish (Pelteobagrus filvidraco) in response to Edwardsiella ictaluri challenge. Fish & Shellfish Immunology, 2018, 80: 250-263.

13. Zhang Xiaoting, Wei Kaijian, Chen Yuanyuan, Shi Zechao, Liu Lingke, Li Jjing, Zhang Guirong, Ji Wei*. Molecular cloning and expression analysis of tyr and tyrp1 genes in normal and albino yellow catfsh Tachysurus fulvidraco. Journal of Fish Biology, 2018, 92: 979-998.

14. Zhang Xiaoting, Zhang Guirong, Shi Zechao, Yuan Yujie, Zheng Huan, Lin Li, Wei Kaijian*, Ji Wei*. Expression analysis of nine Toll-like receptors in yellow catfish (Pelteobagrus fulvidraco) responding to Aeromonas hydrophila challenge. Fish & Shellfish Immunology, 2017, 63: 384-393.

15. Zheng Huan, Ji Wei, Zhang Guirong, Zhang Xiaoting, Shi Zechao, Wei Kaijian, Yang Ruibin, Gardner JPA. Molecular Characterization and Expression  Analyses of the Complement Component C8α, C8β and C9 Genes in Yellow Catfish (Pelteobagrus fulvidraco) after the Aeromonas hydrophila  Challenge. International Journal of Molecular Sciences, 2016, 17(3): 345. (并列第一作者)

16. Ji Wei, Ping Haichao, Wei Kaijian, Zhang Guirong, Shi Zechao, Yang Ruibin, Zou Guiwei, Wang Weimin. Ghrelin, neuropeptide Y (NPY) and cholecystokinin (CCK) in blunt snout bream (Megalobrama amblycephala): cDNA cloning, tissue distribution and mRNA expression changes responding to fasting and refeeding. General and Comparative Endocrinology, 2015 223: 108-119. (并列第一作者)

17. Zou Ming, Zhang Xiaoting, Shi Zechao, Lin Li, Ouyang Gang, Zhang Guirong, Zheng Huan, Wei Kaijian, Ji Wei*. A Comparative Transcriptome Analysis between Wild and Albino Yellow Catfish (Pelteobagrus fulvidraco). PloS ONE, 2015, 10(6): e0131504.

18. Ji Wei, Zhang Guirong, Ran Wei, Gardner JPA, Wei Kaijian, Wang Weimin, Zou Guiwei. Genetic diversity of and differentiation among five populations of blunt snout bream (Megalobrama amblycephala) revealed by SRAP markers: implications for conservation and management. PloS ONE, 2014, 9(9): e108967. (并列第一作者)

19. Ji Wei, Wang Jing, Zhang Wei, Liu Xing, Xiao Wuhan, Ouyang Gang. pVHL acts as a down-stream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457:185-195 .

20. Liang Tao, Ji Wei, Zhang Guirong, Wei Kaijian, Feng Ke, Wang Weimin, Zou Guiwei. 2013. Molecular cloning and expression analysis of liver-expressed antimicrobial peptide 1 (LEAP-1) and LEAP-2 genes in the blunt snout bream (Megalobrama amblycephala). Fish & Shellfish Immunology, 2013, 35(2): 553-563. (并列第一作者)

21. Ji Wei, Liang Hualei, Zhou Wenshan, Zhang Xuezhen. Apoptotic responses of zebrafish (Danio rerio) after exposure with microcystin-LR under different ambient temperatures. Journal of Applied Toxicology, 2013, 33:799-806.

22. Ji Wei, Zhang Guirong, Wei Kaijian, Guo Shanshan, Guo Xiangzhao, Wei Qiwei. Characterization of the complete mitochondrial genome of Oxygymnocypris stewartii (Cypriniformes: Cyprinidae). Mitochondrial DNA, 2015, 26(5): 684-685. (并列第一作者)

23. Zhang Guirong, Ji Wei, Shi Zechao, Wei Kaijian, Guo Xiangzhao, Xie Congxin, Wei Qiwei. The complete mitogenome sequence of Ptychobarbus dipogon (Cypriniformes: Cyprinidae). Mitochnodrial DNA, 2015, 26(5): 710-711. (并列第一作者)

24. Chen Yu , Zhou Chi, Ji Wei, Mei Zhichao, Hu Bo, Zhang Wei, Zhang Dawei, Wang Jing, Liu Xing, Ouyang Gang, Zhou Jiangang, Xiao Wuhan. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth.Nature Communications, 2016, 7: 11057.

25. 14. Zhang Wei, Ji Wei, Liu Xing, Ouyang Gang, Xiao Wuhan.    ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1. Molecular and cell biology, 2014, 34(4):765-775.

26. 姬 伟，魏开建，张桂蓉，史则超。江西青岚湖五种淡水蚌遗传多样性的微卫星 DNA 分析。 农业生物技术学报, 2007,15(3):429-433。（国内一级核心期刊）

27.王京真，姬伟，肖武汉，王丁。长江江豚脐静脉细胞体外培养的初步研究。水生生物学报，2010，34（2）:436-441（国内一级核心期刊）

 备注 

主要研究水生动物先天性免疫在抵抗病原微生物入侵中的作用机制、免疫球蛋白在抗病原感染过程中的作用及机制，并同时开展鱼类疾病的微生态及免疫防控研究。主持国家自然科学基金1项，湖北省自然科学基金1项，中科院水生所开放课题3项，中国水产科学院长江所开放课题1项，横向课题2项，获批发明专利1项。从事动物学等相关课程的教学工作，主持《动物学》国家级一流本科在线开放课程，曾获教学质量优秀三等奖，全国生命科学类微课竞赛二等奖等。目前，在读硕士研究生7名，毕业9名，两名研究生获得国家奖学金。指导两个本科生团队获得全国大学生生命科学竞赛一等奖。